Protontricks
Protontricks (opens in a new tab) is a wrapper for running Winetricks commands, which is designed for Proton. This makes running executables for Flight Simulator much easier.
Installation
Installing Protontricks should be quite simple, as there are multiple methods of installing it depending on your distribution. You can find the documentation for installing it on their GitHub repository here (opens in a new tab).
Usage
Protontricks Launcher
Some Desktop Environments will be able to run the file directly in Protontricks if you can right-click the installer
and open it with Protontricks Launcher

And then select Microsoft Flight Simulator as the Wine prefix

Terminal
If you do not have the option to run Protontricks Launcher, you'll have to manually run it in the terminal with
protontricks 1250410 --guiIgnore all the warnings that will pop up, as this will not affect the installation.
Once the Winetricks window pops up, OK on Select the default wineprefix

Then select Run explorer and click OK

Which will pop up a window for Flight Simulator's Wine directory, where you'll need to navigate through Linux's
directory (with the drive that has /), where you can find the executable and run it.

Uninstalling Applications
The easiest way to uninstall addons/applications would be to run Protontricks in the terminal and instead
of selecting Run explorer, select Run uninstaller

This will open up a window where you can uninstall other addons/applications you have installed for Flight Simulator
